Polić's Group's Work Published
Tuesday, Mar 03 2015

The scientific work of Prof. Bojan Polić's, M.D., Ph.D., group from the Rijeka Faculty of Medicine Institute of Histology and Embryology entitled NK cells link obesity-induced adipose stress to inflammation and insulin resistance was accepted for publication in the prominent journal Nature Immunology.

The scientific work was completely formulated, from idea to realization, at the Rijeka Faculty of Medicine Institute of Histology and Embryology, which is a rarity in Croatia. The scientific work was published on March 2 as an "advanced online publication", while the whole body of work will be published in the print edition of the prominent scientific journal Nature Immunology.

This work represents results of two and a half years worth of intensive research in a field rather new for Croatia - the emerging field of immunometabolism. Namely, this research examins visceral adipose tissue mechanisms (VAT) in terms of thickness, as the main source of low-intensity systemic chronic inflammation which leads to the development of peripheral resistance to insulin (IR) as well as subsequent development of Diabetes Mellitus type 2 (DM2) and further complications.

Significant contributors to this work include its first author, Dr. Felix M. Wensveen, a postdoc within Prof. Polić's group and as of recently an Assistant Professor at the Rijeka Faculty of Medicine Institute of Histology and Embryology, along with the other contributors, the younger group members: Vedrana Jelenčić, mag. biotech., Sonja Valentić, mag. mol. biol., and Marko Šestan, dr. med. vet.

Significant contributors to the clinical part of the study are: Dr. Tamara Turk Wensveen and Prof. Davor Štimac, M.D., Ph.D., from the Internal Medicine Clinic, and Dr. Davor Mendrila from the Surgery Clinic. Likewise, it is of vital importance to mention the broader part of the clinical team who participated in research, as follows: prof. Dubravka Jurišić Eržen, dr. Sanja Klobučar Majanović, Neven Franjić from the Internal Medicine Clinic, along with dr. Marko Zelić from the Surgery Clinic. Our fellow foreign associates greatly helped out with their respective advice, counselling, reangents, and specific expertise, esp. Prof. Ofer Mandelboim's group  and associate Ariella Glasner from The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel; as well as Prof. Jens Bruening's group along with Prof. Thomas Wunderlich and Sebastian Theurich from the Max Planck Institute for Metabolism Research Cologne, Cologne, Germany. 


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